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Serotonin or 5-hydroxytryptamine (5-HT) is synthesized in both the brain and peripheral system, which exert their actions at a wide family of receptors classified as 5-HT1 to 5-HT7. Pharmacological, behavioral, and clinical studies involve particularly to the 5-HT1A receptors (5-HT1A-R) – auto-receptors (presynaptic) and heteroreceptors (postsynaptic) – in the control of motivated behavior Drug class: Specific drugs: Subgroup: Examples: Sedatives, Benzodiazepines Benzodiazepine agonists, Zolpidem (Ambien), eszopiclone (Lunesta), zopiclone by RL Jakab 2024 Cited by Hydroxytryptamine2A (5-HT2A) serotonin receptors are involved in the actions of hallucinogenic drugs and have been implicated in the pathogenesis and gavilyte-g solution reviews by EW Boyer Cited by 39Although counterintuitive, serotonergic agonists that have their effect directly on postsynaptic 5-HT drug-drug interactions or MAOIs drug LSD is an artificial agonist of the 5-HT2A receptors. Agonist drugs are structurally similar to the natural agonists in the human body. Based on the lack of clinical efficacy for treatment of schizophrenia by selective 5-HT 2A receptor inverse agonists (e.g, pimavanserin) and the selective 5-HT 2C receptor agonist, vabicaserin, its intriguing to speculate that ligands that are selective for a single receptor subtype regardless of the drug property (i.e, agonist or inverse